Saturday, July 18, 2020

PROTON THERAPY. (A treatment for Cancers)

Hii..I am Gourav and in this blog I am going to share something about CANCER with you..

National Health profile 2019 revealed that there were nearly 258 cancer patients recorded per lakh of population in 2019 in India , which was earlier 106 cancer patients per lakh population in 2016

By this we can know that how the number of Cancer patients is increasing year by year in India,  in present scenario this problem is not only facing by India but also the whole world is facing such problem.

Let's know more about cancer.....

WHAT IS CANCER ?

In my point of view we cannot say a cancer as a disease rather it is a condition in which the cell divides uncontrollably and abnormally which     results in tissue destruction....

Cancer are of many types like breast cancer, prostate cancer , basal cell cancer , skin cancer, colon cancer etc...

Out to these the lung cancer, breast cancer and prostate cancer are the most common type of cancer.

TREATMENT

many procedures and drugs are available which are commonly used for treating cancer.
Some are local treatment like surgery and Radiation therapy which are used to treat specific tumor.
And some are systemic  treatments which includes chemotherapy , immunotherapy etc...

But in this blog l am going to share something about Proton Therapy , which is a new step in the treatment of cancer with fewer side effects in comparison to other traditional treatment for cancer

PROTON THERAPY :-

Proton therapy is a type of Radiation therapy which is used to treat cancer.
In this therapy the Proton beams are used instead of X rays..
The X rays as radiation therapy is a traditional way to treat cancer..Now a days it is not so much used as it has some side effects and can harm the healthy tissues..

In this therapy the high energy protons are used to destroy the cancer cells.

It is a type of external beam Radiation therapy which painlessly delivers the radiation inside the body through skin from machine outside the body without affecting the healthy tissues..

HOW IT WORKS :-

The protons are deliver by a machine called synchrotron or cyclotron which speeds up protons and the high speed of protons creates high energy.
This high energy Proton can easily penetrate deep inside the body to the targeted side with targeted radiation dose..
In Proton therapy there is less radiation dose outside the tumor it means that it effect less healthy tissues and have fewer Side Effects than the traditional Radiation therapy..

MACHINES USED FOR DELIVERING PROTONS -

Synchrotron and cyclotron is used to deliver the proton beam.

This machines accelerate Proton to speed upto 60% the speed of light and energies of 250 million electron volts.

This high energy Proton are steered by magnet toward the treatment room and then to specific part of the body being treated...

The magnetic field created by the magnet guide the part of the proton being and delivers the proton beam where the energy needed to destroy the tumor cells..

CANCERS IN WHICH PROTON THERAPY IS USED  :-

Proton therapy is being used to treat tumors in in different areas of the body with encouraging early results.
It is mainly used in following cases :-
Lungs cancer
Prostate cancer
Breast cancer
Oesophagus cancer
Rectum cancer
Liver cancer
Skull base carcomas
Paediatric brain tumor
Head and neck cancer
Eye melanomas..

DURATION OF PROTON THERAPY -

Once the tumors location is accurately determined Proton therapy sessions may take anywhere from 4 to 8 weeks..

The appointment usually takes 15 to 45 minutes but the actual time the proton therapy takes to deliver the proton beam is only 1- 3 months on average..

PROTON THERAPY IN INDIA :-

Recently India becomes 16th country in the world to offer Proton therapy..

Apollo Proton Cancer Centre (APCC) is providing this treatment in India.

The entire treatment will cost about 25 to 30 lakh rupees for a patient , which is a very huge amount to be paid by a middle class family in India..So, in India many patients goes for Chemotherapy as a treatment for cancer..

BENEFITS OF PROTON THERAPY :-

In comparison to other Radiation therapy Proton therapy has several benefits :-

- Usually the proton therapy delivers 60% less radiation to Healthy tissues as compared to other Radiation therapy.

- It allows high radiation dose to the tumor which may increase the chances of destroying all tumor cells.

- It has very less Side Effects as compared to other Radiation therapy.

DRAWBACKS OFPROTON THERAPY :-

As we know that there is nothing in the world which is 100% perfect so in that point of view the proton therapy has also some drawbacks -

- It is very much costly as compared to X Ray Radiation therapy.

- Not all cancer can be treated by Proton therapy

- In many places there is in availability of the documents on machines which are used for delivering the proton beam...


Monday, July 13, 2020

DOTS THERAPY (Directly Observed Therapy , Short Course). "A THERAPY FOR TUBERCULOSIS"

TUBERCULOSIS

It is a chronic granulomatous inflammatory disorder. It is caused by bacteria Microbacterium tuberculosis.
It is called as " king of diseases " is it is very much difficult to treat.
The bacteria that causes TB are spread when an infected person cough or sneezes.

DOTS THERAPY

DOTS stands for "Directly Observed Treatment Short course)
It was developed by Karel Styblo of International Union against TB and lung diseases in 1970 primarily in Tanzania
TB requires at least six months for the treatment
if treatment is incompleted or discontinued the patient may not be cure and the drug resistance may developed
Directly Observed therapy is a specific strategy which is done to improve adherence by requiring health workers community volunteers for family members to observe and record patients taking each dose.

COMPONENTS OF DOTS

It has five main components :-

- Government Commitment

Here the Government of the particular region establish centralised and prioritised system of TB monitoring recording and tracing.

- Case Detection

The case this section is done by sputum smear microscopy.

- Standardized Treatment

it includes 6 to 9 months therapy which is observed by a Health Care worker or community health worker for at least the first two months.

- Drug Supply

- A standardized recording and reporting system that allows assessment of treatment result.

PHASES OF DOTS THERAPY

There are two phases of DOTS Therapy :-

INTENSIVE PHASE :-

It is of two to three months of duration. in this space the patient has to swallow medicine under the observation of health worker during IP
Medicines are taken 3 times a week on alternative days
If the sputum is negative for bacteria after IP Continuation Phase is started..

CONTINUATION PHASE :-

This phase is of 4 to 5 months duration.
Here the patient is provided with a weekly blister pack to take home.
The medications from the blister pack are taken on alternative days three times a week and in the remaining days vitamin tablet are taken.
The first dose of the weekly blister pack is taken under direct observation of the health worker.
Empty blistera packs are collected to ensure that the medications are taken at home by the patients

DRUG USED IN DIFFERENT PHASES OF DOTS THERAPY

DRUGS TAKEN IN INITIAL PHASE

- ISONIAZID (H)
- RIFAMPICIN (R)
- PYRAZINAMIDE (Z)
- ETHAMBUTOL (E)
- PYRIDOXINE  (Vit. B6) 100 mg/ day

DRUGS TAKEN IN CONTINUATION PHASE

- ISONIAZID
- RIFAMPICIN
- PYRIDOXINE (Vit B6)

OBJECTIVES OF TB TREATMENT

- TO KILL ACTIVELY DIVIDING BACTERIA - RELIEVE SIGNS AND SYMPTOMS - ISONIAZID
- TO KILL SLOWLY DIVIDING AND PERSISTENT         BACTERIA ERADICATE THE DISEASE AND     PREVENT RELAPSE -  RIFAMPICIN AND PYRAZINAMIDE
- TO PREVENT EMERGENCE OF DRUG           RESISTANCE - ETHAMBUTOL

ADVANTAGES OF DOTS THERAPY

- It ensure that patient completes an adequate     regimen
- It lets the health care worker to monitor patient   regularly for side effects and response to therapy
- It helps the health care worker to solve problems that might interrupt the treatment
- It helps in ensuring that the patient takes every dose of medicines and also it helps patient to become noninfectious Sooner.

DISADVANTAGES OF DOTS THERAPY

- It is the time consuming therapy
- It is labour intensive
- It can be perceived as demeaning or punitive

Sunday, July 12, 2020

NOOTROPICS ( Smart drugs or Cognitive enhancers)

Firstly we should know what is the meaning of cognition.

COGNITION - It is the process by which knowledge and understanding is developed in the mind.

The healthy mind plays an important role in playing a healthy and happy life..

LETS KNOW ABOUT NOOTROOPICS DRUGS


Nootroopics are drug, supplements and substances that improve the cognitive function particularly executive function,memory creativity or motivation in health individuals.

CLASSIFICATION

  1. RACETAM (Piracetam) - It is the first nootropic agent discovered.
  2. ACETYLCHOLINEEE PRECURSORS -Lecithin
  3. ACETYLCHOLINESTERASE INHIBITOR - Huperzine A   
  4. AMPAKINES (Aniracetam) 
  5. HERBALS - 

  • Bacopa monneri
  • Vinpocetin
  • Gingko biloba
  • Gotu kola
  • 6. OTHER NOOTROPICS
  • Pyritinol
  • Citicholine
  • Sulbutiami
  • Noopept

  • 7.PRESCRIPTION NOOTROPICS
  • Provigil
  • Adderall
  • Methylphenidate
  • Meantine
  • HOW NOOTROPICS WORKS

  • It act on blood vessels and causes vasodilation due to which the blood flow to the Brain increases

  • As more blood flows to cerebrum so more oxygen supplements and glucose is utilised by the brain

  • Performing mental activities, adapting to new things ,focusing on work and staying focus all day burns lots of calories by raising blood flow and oxygenation , you immediately experience increase in memory and focus.

  • BENEFITS OF NOOTROPICS

  • Increasing blood flow
  • Enhancing neurotransmission
  • Increases stimulation of hormones and enzymes
  • Increased growth factor
  • It also helps in improving memory and mental health
  • It also helps in reducing anxiety.

SIDE EFFECTS OF PRESCRIPTION NOOTROPICS 

  • High blood pressure
  • Fast heart rate
  • Insomnia
  • Trouble with vision
  • Addiction